Drug interactions
Celecoxib + Methamphetamine
Severity: Minor
Celecoxib and Methamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib inhibits CYP2D6, which contributes to methamphetamine metabolism, so exposure could rise modestly. The clinical significance is uncertain and likely small.
What this interaction means in plain words
Celecoxib and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Methamphetamine belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by celecoxib may reduce methamphetamine hydroxylation.
What to do
No dose change is routinely needed. Watch for increased sympathomimetic effects such as tachycardia and hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Celecoxib with Methamphetamine?
MediHelp rates the interaction as minor. Celecoxib and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib inhibits CYP2D6, which contributes to methamphetamine metabolism, so exposure could rise modestly. The clinical significance is uncertain and likely small.
How serious is the interaction between Celecoxib and Methamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Watch for increased sympathomimetic effects such as tachycardia and hypertension.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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