Drug interactions
Celecoxib + Oxycodone
Severity: Minor
Celecoxib and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a weak CYP2D6 inhibitor, but oxycodone is metabolized mainly by CYP3A4, so a meaningful change in opioid exposure is unlikely. The combination is commonly used for multimodal analgesia without a significant pharmacokinetic problem.
What this interaction means in plain words
Celecoxib and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Oxycodone belongs to Musculoskeletal.
Why it happens
Weak CYP2D6 inhibition by celecoxib has little effect on oxycodone, which depends mainly on CYP3A4 for clearance.
What to do
No dose change is needed; monitor for the usual opioid effects such as sedation and respiratory depression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Celecoxib with Oxycodone?
MediHelp rates the interaction as minor. Celecoxib and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib is a weak CYP2D6 inhibitor, but oxycodone is metabolized mainly by CYP3A4, so a meaningful change in opioid exposure is unlikely. The combination is commonly used for multimodal analgesia without a significant pharmacokinetic problem.
How serious is the interaction between Celecoxib and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for the usual opioid effects such as sedation and respiratory depression.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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