Drug interactions
Celecoxib + Risperidone
Severity: Minor
Celecoxib and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may slightly raise risperidone levels via weak CYP2D6 inhibition. Because the active moiety includes 9-hydroxyrisperidone, the net clinical effect is likely small.
What this interaction means in plain words
Celecoxib and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Risperidone belongs to Central Nervous System.
Why it happens
Celecoxib weakly inhibits CYP2D6, which converts risperidone to 9-hydroxyrisperidone.
What to do
No dose change is typically needed; monitor for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Celecoxib with Risperidone?
MediHelp rates the interaction as minor. Celecoxib and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib may slightly raise risperidone levels via weak CYP2D6 inhibition. Because the active moiety includes 9-hydroxyrisperidone, the net clinical effect is likely small.
How serious is the interaction between Celecoxib and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically needed; monitor for extrapyramidal symptoms and sedation.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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