Drug interactions
Celecoxib + Rucaparib
Severity: Minor
Celecoxib and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9 in vitro and in clinical studies raised exposure to CYP2C9 substrates modestly. Celecoxib is cleared mainly by CYP2C9, so its levels and NSAID-related adverse effects may rise.
What this interaction means in plain words
Celecoxib and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C9, reducing the metabolic clearance of celecoxib.
What to do
Watch for gastrointestinal, renal and cardiovascular adverse effects of celecoxib when starting rucaparib. Reduce the celecoxib dose if signs of excess exposure appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Celecoxib with Rucaparib?
MediHelp rates the interaction as minor. Celecoxib and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP2C9 in vitro and in clinical studies raised exposure to CYP2C9 substrates modestly. Celecoxib is cleared mainly by CYP2C9, so its levels and NSAID-related adverse effects may rise.
How serious is the interaction between Celecoxib and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for gastrointestinal, renal and cardiovascular adverse effects of celecoxib when starting rucaparib. Reduce the celecoxib dose if signs of excess exposure appear.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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