Drug interactions
Celecoxib + Sotalol
Severity: Moderate
Celecoxib and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce the antihypertensive effect of beta-blockers such as sotalol. Renal impairment caused by NSAIDs can also raise sotalol levels, since it is renally cleared, increasing the risk of QT prolongation.
What this interaction means in plain words
Celecoxib and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Sotalol belongs to Cardiovascular.
Why it happens
Prostaglandin inhibition causes fluid retention and may reduce renal function, opposing blood pressure control and reducing sotalol clearance.
What to do
Monitor blood pressure, renal function and QTc, especially in patients with kidney disease or on prolonged NSAID therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Celecoxib with Sotalol?
MediHelp rates the interaction as moderate. Celecoxib and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce the antihypertensive effect of beta-blockers such as sotalol. Renal impairment caused by NSAIDs can also raise sotalol levels, since it is renally cleared, increasing the risk of QT prolongation.
How serious is the interaction between Celecoxib and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and QTc, especially in patients with kidney disease or on prolonged NSAID therapy.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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