Drug interactions
Celecoxib + Tramadol
Severity: Minor
Celecoxib and Tramadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tramadol requires CYP2D6 activation to its more potent opioid metabolite, and celecoxib weakly inhibits this enzyme. A clinically meaningful loss of analgesia is unlikely, and the combination is often used together for pain.
What this interaction means in plain words
Celecoxib and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Tramadol belongs to Musculoskeletal.
Why it happens
Weak CYP2D6 inhibition by celecoxib may slightly reduce formation of O-desmethyltramadol.
What to do
No dose adjustment is usually needed; reassess pain control if response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Celecoxib with Tramadol?
MediHelp rates the interaction as minor. Celecoxib and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tramadol requires CYP2D6 activation to its more potent opioid metabolite, and celecoxib weakly inhibits this enzyme. A clinically meaningful loss of analgesia is unlikely, and the combination is often used together for pain.
How serious is the interaction between Celecoxib and Tramadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; reassess pain control if response is poor.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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