Drug interactions
Cenobamate + Fenofibrate
Severity: Minor
Cenobamate and Fenofibrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and could reduce levels of CYP3A4 substrates. Fenofibric acid is cleared mainly by glucuronidation, so a meaningful effect is not expected.
What this interaction means in plain words
Cenobamate and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cenobamate belongs to Central Nervous System; Fenofibrate belongs to Cardiovascular.
Why it happens
Cenobamate induces CYP3A4, which is a minor pathway for fenofibrate, so any effect is predicted rather than demonstrated.
What to do
No empiric dose change is needed. Check the lipid response if cenobamate is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Fenofibrate?
MediHelp rates the interaction as minor. Cenobamate and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cenobamate induces CYP3A4 and could reduce levels of CYP3A4 substrates. Fenofibric acid is cleared mainly by glucuronidation, so a meaningful effect is not expected.
How serious is the interaction between Cenobamate and Fenofibrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Check the lipid response if cenobamate is started or stopped.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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