Drug interactions
Cyclosporin + Fenofibrate
Severity: Moderate
Cyclosporin and Fenofibrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates given with cyclosporin have been associated with reversible rises in serum creatinine and reduced renal function. Cyclosporin levels may change in some patients.
What this interaction means in plain words
Cyclosporin and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Fenofibrate belongs to Cardiovascular.
Why it happens
Likely additive renal hemodynamic effects; the effect on cyclosporin concentrations is not well established.
What to do
Monitor serum creatinine and cyclosporin trough levels after starting fenofibrate, and stop the fibrate if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Cyclosporin with Fenofibrate?
MediHelp rates the interaction as moderate. Cyclosporin and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates given with cyclosporin have been associated with reversible rises in serum creatinine and reduced renal function. Cyclosporin levels may change in some patients.
How serious is the interaction between Cyclosporin and Fenofibrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and cyclosporin trough levels after starting fenofibrate, and stop the fibrate if renal function deteriorates.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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