Drug interactions
Colchicine + Fenofibrate
Severity: Moderate
Colchicine and Fenofibrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause myopathy, and the combination has been associated with rhabdomyolysis. Risk is higher with renal impairment and advanced age.
What this interaction means in plain words
Colchicine and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Fenofibrate belongs to Cardiovascular.
Why it happens
Additive myotoxicity.
What to do
Counsel patients to report muscle pain or weakness, and check creatine kinase if symptoms develop. Adjust colchicine dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Frequently asked questions
Can I take Colchicine with Fenofibrate?
MediHelp rates the interaction as moderate. Colchicine and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause myopathy, and the combination has been associated with rhabdomyolysis. Risk is higher with renal impairment and advanced age.
How serious is the interaction between Colchicine and Fenofibrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report muscle pain or weakness, and check creatine kinase if symptoms develop. Adjust colchicine dose in renal impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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