Drug interactions
Colestipol + Fenofibrate
Severity: Moderate
Colestipol and Fenofibrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol binds fenofibrate in the gut and can reduce its absorption. Lower exposure could weaken the lipid-lowering effect of fenofibrate.
What this interaction means in plain words
Colestipol and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Fenofibrate belongs to Cardiovascular.
Why it happens
Colestipol binds fenofibrate or fenofibric acid in the gastrointestinal lumen and reduces absorption.
What to do
Give fenofibrate at least 1 hour before or 4 to 6 hours after colestipol. Check the lipid response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Fenofibrate?
MediHelp rates the interaction as moderate. Colestipol and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol binds fenofibrate in the gut and can reduce its absorption. Lower exposure could weaken the lipid-lowering effect of fenofibrate.
How serious is the interaction between Colestipol and Fenofibrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give fenofibrate at least 1 hour before or 4 to 6 hours after colestipol. Check the lipid response.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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