Drug interactions
Atorvastatin + Fenofibrate
Severity: Moderate
Atorvastatin and Fenofibrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drug classes can cause myopathy, and combining them modestly increases the risk of muscle toxicity including rhabdomyolysis. Fenofibrate carries lower risk than gemfibrozil and is often used for mixed dyslipidemia.
What this interaction means in plain words
Atorvastatin and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Fenofibrate belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic myotoxicity.
What to do
Use the lowest effective doses and counsel patients to report muscle symptoms. Check CK if symptoms occur and monitor renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Fenofibrate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Frequently asked questions
Can I take Atorvastatin with Fenofibrate?
MediHelp rates the interaction as moderate. Atorvastatin and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drug classes can cause myopathy, and combining them modestly increases the risk of muscle toxicity including rhabdomyolysis. Fenofibrate carries lower risk than gemfibrozil and is often used for mixed dyslipidemia.
How serious is the interaction between Atorvastatin and Fenofibrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients to report muscle symptoms. Check CK if symptoms occur and monitor renal function.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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