Drug interactions
Cholic acid + Fenofibrate
Severity: Moderate
Cholic acid and Fenofibrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholic acid labeling advises avoiding drugs that inhibit the bile salt export pump because they may cause conjugated bile salts to accumulate in the liver. Fenofibrate is not a well-established BSEP inhibitor, and fibrates can also raise biliary cholesterol saturation. The concern is mainly theoretical but involves liver injury.
What this interaction means in plain words
Cholic acid and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Fenofibrate belongs to Cardiovascular.
Why it happens
Possible inhibition of the bile salt export pump leading to hepatic bile salt accumulation; this is not firmly established for fenofibrate.
What to do
Monitor serum transaminases and bilirubin if the combination is used. Stop cholic acid or review therapy if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Fenofibrate?
MediHelp rates the interaction as moderate. Cholic acid and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholic acid labeling advises avoiding drugs that inhibit the bile salt export pump because they may cause conjugated bile salts to accumulate in the liver. Fenofibrate is not a well-established BSEP inhibitor, and fibrates can also raise biliary cholesterol saturation. The concern is mainly theoretical but involves liver injury.
How serious is the interaction between Cholic acid and Fenofibrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum transaminases and bilirubin if the combination is used. Stop cholic acid or review therapy if liver injury develops.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Colchicine. The full list is on the Fenofibrate page.
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