Drug interactions
Cenobamate + Rolapitant
Severity: Moderate
Cenobamate and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and may lower rolapitant exposure. Reduced rolapitant concentrations could decrease protection against delayed chemotherapy-induced nausea and vomiting.
What this interaction means in plain words
Cenobamate and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Induction of CYP3A4 by cenobamate increases rolapitant clearance.
What to do
Monitor antiemetic efficacy and add or optimize other antiemetics if breakthrough nausea occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Rolapitant?
MediHelp rates the interaction as moderate. Cenobamate and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate is a CYP3A4 inducer and may lower rolapitant exposure. Reduced rolapitant concentrations could decrease protection against delayed chemotherapy-induced nausea and vomiting.
How serious is the interaction between Cenobamate and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antiemetic efficacy and add or optimize other antiemetics if breakthrough nausea occurs.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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