Drug interactions
Ceritinib + Chloramphenicol
Severity: Moderate
Ceritinib and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 substrate with QT-prolonging and hepatotoxic potential, and chloramphenicol may raise its concentrations. This could increase gastrointestinal, hepatic and cardiac toxicity.
What this interaction means in plain words
Ceritinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ceritinib.
What to do
Avoid if possible. If used, consider reducing the ceritinib dose per labeling for CYP3A inhibitors and monitor ECG, electrolytes and liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Chloramphenicol?
MediHelp rates the interaction as moderate. Ceritinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a CYP3A4 substrate with QT-prolonging and hepatotoxic potential, and chloramphenicol may raise its concentrations. This could increase gastrointestinal, hepatic and cardiac toxicity.
How serious is the interaction between Ceritinib and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, consider reducing the ceritinib dose per labeling for CYP3A inhibitors and monitor ECG, electrolytes and liver tests.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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