Drug interactions
Ceritinib + Chlordiazepoxide-clidinium
Severity: Moderate
Ceritinib and Chlordiazepoxide-clidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise chlordiazepoxide exposure. This can deepen sedation, impair psychomotor performance and increase the risk of respiratory depression.
What this interaction means in plain words
Ceritinib and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
Why it happens
Ceritinib inhibits CYP3A4-mediated oxidative metabolism of chlordiazepoxide, reducing its clearance.
What to do
Monitor for excess sedation and confusion, particularly in older patients, and reduce the chlordiazepoxide dose if needed. Consider a non-CYP3A4-dependent benzodiazepine if long-term coadministration is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceritinib and Chlordiazepoxide-clidinium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as moderate. Ceritinib and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise chlordiazepoxide exposure. This can deepen sedation, impair psychomotor performance and increase the risk of respiratory depression.
How serious is the interaction between Ceritinib and Chlordiazepoxide-clidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and confusion, particularly in older patients, and reduce the chlordiazepoxide dose if needed. Consider a non-CYP3A4-dependent benzodiazepine if long-term coadministration is required.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
