Drug interactions
Ceritinib + Cilostazol
Severity: Moderate
Ceritinib and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and can raise cilostazol exposure. Higher cilostazol levels increase the risk of headache, tachycardia, palpitations, diarrhea and other dose-related adverse effects.
What this interaction means in plain words
Ceritinib and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Cilostazol belongs to Cardiovascular.
Why it happens
Ceritinib inhibits CYP3A4, reducing the metabolic clearance of cilostazol.
What to do
Consider reducing cilostazol to 50 mg twice daily while ceritinib is given, and monitor heart rate and tolerability. Choose an alternative if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Cilostazol?
MediHelp rates the interaction as moderate. Ceritinib and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and can raise cilostazol exposure. Higher cilostazol levels increase the risk of headache, tachycardia, palpitations, diarrhea and other dose-related adverse effects.
How serious is the interaction between Ceritinib and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily while ceritinib is given, and monitor heart rate and tolerability. Choose an alternative if adverse effects occur.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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