Drug interactions
Ceritinib + Dexlansoprazole
Severity: Minor
Ceritinib and Dexlansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4, which has a minor role in dexlansoprazole clearance. Dexlansoprazole exposure may rise somewhat, but a clinically significant effect is unlikely. Ceritinib's own absorption is pH-dependent, particularly when taken fasted.
What this interaction means in plain words
Ceritinib and Dexlansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceritinib belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Ceritinib inhibits CYP3A4, a secondary pathway for dexlansoprazole metabolism.
What to do
No dose change is needed. Monitor for dexlansoprazole adverse effects and ceritinib efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Dexlansoprazole?
MediHelp rates the interaction as minor. Ceritinib and Dexlansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceritinib inhibits CYP3A4, which has a minor role in dexlansoprazole clearance. Dexlansoprazole exposure may rise somewhat, but a clinically significant effect is unlikely. Ceritinib's own absorption is pH-dependent, particularly when taken fasted.
How serious is the interaction between Ceritinib and Dexlansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for dexlansoprazole adverse effects and ceritinib efficacy.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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