Drug interactions
Ceritinib + Felodipine
Severity: Moderate
Ceritinib and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise felodipine concentrations, causing hypotension and oedema. Ceritinib can also cause bradycardia and QT prolongation, which complicates cardiovascular effects.
What this interaction means in plain words
Ceritinib and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Felodipine belongs to Cardiovascular.
Why it happens
Ceritinib inhibits CYP3A4-mediated felodipine metabolism.
What to do
Monitor blood pressure and heart rate, and reduce the felodipine dose if hypotension or oedema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Felodipine?
MediHelp rates the interaction as moderate. Ceritinib and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise felodipine concentrations, causing hypotension and oedema. Ceritinib can also cause bradycardia and QT prolongation, which complicates cardiovascular effects.
How serious is the interaction between Ceritinib and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and reduce the felodipine dose if hypotension or oedema develops.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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