Drug interactions
Ceritinib + Flecainide
Severity: Major
Ceritinib and Flecainide: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib can cause dose-dependent QT prolongation and bradycardia, and flecainide slows cardiac conduction. The combination may increase the risk of serious arrhythmia.
What this interaction means in plain words
Ceritinib and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Flecainide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on cardiac conduction and repolarization.
What to do
Avoid the combination where possible. If it cannot be avoided, perform serial ECGs, monitor electrolytes and heart rate, and withhold ceritinib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Flecainide?
MediHelp rates the interaction as major. Ceritinib and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib can cause dose-dependent QT prolongation and bradycardia, and flecainide slows cardiac conduction. The combination may increase the risk of serious arrhythmia.
How serious is the interaction between Ceritinib and Flecainide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it cannot be avoided, perform serial ECGs, monitor electrolytes and heart rate, and withhold ceritinib if the QTc becomes markedly prolonged.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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