Drug interactions
Ceritinib + Fluticasone
Severity: Moderate
Ceritinib and Fluticasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise fluticasone exposure. Systemic corticosteroid effects are more likely with prolonged use or higher doses.
What this interaction means in plain words
Ceritinib and Fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Fluticasone belongs to Respiratory.
Why it happens
Ceritinib inhibits CYP3A4, reducing fluticasone first-pass and systemic clearance.
What to do
Monitor for corticosteroid systemic effects such as Cushingoid features and adrenal suppression with long-term use. Consider an alternative like beclomethasone if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Fluticasone?
MediHelp rates the interaction as moderate. Ceritinib and Fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise fluticasone exposure. Systemic corticosteroid effects are more likely with prolonged use or higher doses.
How serious is the interaction between Ceritinib and Fluticasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid systemic effects such as Cushingoid features and adrenal suppression with long-term use. Consider an alternative like beclomethasone if prolonged therapy is needed.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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