Drug interactions
Ceritinib + Hydrocodone
Severity: Moderate
Ceritinib and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and may raise hydrocodone concentrations. Higher exposure can increase sedation and respiratory depression.
What this interaction means in plain words
Ceritinib and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Hydrocodone belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated metabolism of hydrocodone by ceritinib.
What to do
Monitor for sedation and respiratory depression and consider reducing the hydrocodone dose while on ceritinib. Reassess dosing if ceritinib is stopped, as hydrocodone levels may fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Hydrocodone?
MediHelp rates the interaction as moderate. Ceritinib and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a CYP3A4 inhibitor and may raise hydrocodone concentrations. Higher exposure can increase sedation and respiratory depression.
How serious is the interaction between Ceritinib and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and consider reducing the hydrocodone dose while on ceritinib. Reassess dosing if ceritinib is stopped, as hydrocodone levels may fall.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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