Drug interactions
Ceritinib + Mifepristone
Severity: Major
Ceritinib and Mifepristone: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and can raise mifepristone levels, while both drugs prolong the QTc interval. The combination increases the risk of torsades de pointes.
What this interaction means in plain words
Ceritinib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Additive QTc prolongation plus CYP3A4 inhibition increasing mifepristone exposure.
What to do
Avoid the combination where possible. If used, monitor ECG and electrolytes and watch for mifepristone adverse effects such as hypokalemia and adrenal insufficiency.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Mifepristone?
MediHelp rates the interaction as major. Ceritinib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib is a CYP3A4 inhibitor and can raise mifepristone levels, while both drugs prolong the QTc interval. The combination increases the risk of torsades de pointes.
How serious is the interaction between Ceritinib and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor ECG and electrolytes and watch for mifepristone adverse effects such as hypokalemia and adrenal insufficiency.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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