Drug interactions
Ceritinib + Nicardipine
Severity: Moderate
Ceritinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may raise ceritinib concentrations through CYP3A4 inhibition. Ceritinib toxicity includes QT prolongation, bradycardia, hepatotoxicity and gastrointestinal effects.
What this interaction means in plain words
Ceritinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 by nicardipine decreases ceritinib metabolism.
What to do
Monitor ECG, heart rate, liver enzymes and GI tolerability, and reduce the ceritinib dose if toxicity appears. Use an alternative antihypertensive if QT or bradycardia concerns arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Nicardipine?
MediHelp rates the interaction as moderate. Ceritinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may raise ceritinib concentrations through CYP3A4 inhibition. Ceritinib toxicity includes QT prolongation, bradycardia, hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Ceritinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate, liver enzymes and GI tolerability, and reduce the ceritinib dose if toxicity appears. Use an alternative antihypertensive if QT or bradycardia concerns arise.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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