Drug interactions
Ceritinib + Propafenone
Severity: Major
Ceritinib and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib prolongs the QT interval in a concentration-dependent way and can cause bradycardia. Propafenone adds proarrhythmic and conduction effects, raising the risk of torsade de pointes. Ceritinib also inhibits CYP3A4 and CYP2C9, which may increase propafenone exposure.
What this interaction means in plain words
Ceritinib and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Additive effects on cardiac repolarization and conduction, with possible ceritinib inhibition of CYP3A4-mediated propafenone metabolism.
What to do
Avoid if possible and choose an alternative antiarrhythmic. If coadministered, monitor ECG, heart rate and electrolytes periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Propafenone?
MediHelp rates the interaction as major. Ceritinib and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib prolongs the QT interval in a concentration-dependent way and can cause bradycardia. Propafenone adds proarrhythmic and conduction effects, raising the risk of torsade de pointes. Ceritinib also inhibits CYP3A4 and CYP2C9, which may increase propafenone exposure.
How serious is the interaction between Ceritinib and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative antiarrhythmic. If coadministered, monitor ECG, heart rate and electrolytes periodically.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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