Drug interactions
Ceritinib + Regorafenib
Severity: Moderate
Ceritinib and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may increase regorafenib exposure, though this also lowers its active metabolites, so net effect is uncertain. Increased toxicity such as hepatotoxicity and hypertension is possible, and both drugs carry hepatic risk.
What this interaction means in plain words
Ceritinib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Regorafenib belongs to Oncology.
Why it happens
Ceritinib inhibits CYP3A4, reducing regorafenib metabolism.
What to do
Monitor liver function tests and blood pressure regularly. Interrupt or reduce the dose of either drug if hepatotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Regorafenib?
MediHelp rates the interaction as moderate. Ceritinib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may increase regorafenib exposure, though this also lowers its active metabolites, so net effect is uncertain. Increased toxicity such as hepatotoxicity and hypertension is possible, and both drugs carry hepatic risk.
How serious is the interaction between Ceritinib and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and blood pressure regularly. Interrupt or reduce the dose of either drug if hepatotoxicity develops.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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