Drug interactions
Ceritinib + Roflumilast
Severity: Moderate
Ceritinib and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib may increase roflumilast exposure, raising the risk of adverse effects such as diarrhea, nausea, weight loss, insomnia and psychiatric symptoms. The clinical size of the effect is uncertain.
What this interaction means in plain words
Ceritinib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Roflumilast belongs to Respiratory.
Why it happens
Ceritinib inhibits CYP3A4, reducing the metabolism of roflumilast.
What to do
Monitor for gastrointestinal, weight and neuropsychiatric adverse effects and consider stopping roflumilast if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Roflumilast?
MediHelp rates the interaction as moderate. Ceritinib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib may increase roflumilast exposure, raising the risk of adverse effects such as diarrhea, nausea, weight loss, insomnia and psychiatric symptoms. The clinical size of the effect is uncertain.
How serious is the interaction between Ceritinib and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal, weight and neuropsychiatric adverse effects and consider stopping roflumilast if they emerge.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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