Drug interactions
Ceritinib + Saxagliptin-metformin
Severity: Moderate
Ceritinib and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4, which metabolizes saxagliptin to its active metabolite. Saxagliptin exposure may increase while the active metabolite falls, with a modest net effect.
What this interaction means in plain words
Ceritinib and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Ceritinib inhibits CYP3A4-mediated metabolism of saxagliptin.
What to do
Monitor glycemic control and for saxagliptin adverse effects. Limit the saxagliptin dose to 2.5 mg daily if a strong CYP3A4 inhibitor effect is expected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Ceritinib and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4, which metabolizes saxagliptin to its active metabolite. Saxagliptin exposure may increase while the active metabolite falls, with a modest net effect.
How serious is the interaction between Ceritinib and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and for saxagliptin adverse effects. Limit the saxagliptin dose to 2.5 mg daily if a strong CYP3A4 inhibitor effect is expected.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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