Drug interactions
Ceritinib + Umeclidinium-vilanterol
Severity: Moderate
Ceritinib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and vilanterol is a CYP3A4 substrate, so vilanterol exposure may rise. This can increase beta-agonist effects such as tachycardia, tremor and hypokalemia. Ceritinib itself can prolong QT, which adds to the cardiac concern.
What this interaction means in plain words
Ceritinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vilanterol by ceritinib, with additive QT effects.
What to do
Monitor heart rate, ECG and potassium, and watch for beta-agonist adverse effects. Reassess the need for the combination inhaler if cardiac symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Ceritinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a CYP3A4 inhibitor and vilanterol is a CYP3A4 substrate, so vilanterol exposure may rise. This can increase beta-agonist effects such as tachycardia, tremor and hypokalemia. Ceritinib itself can prolong QT, which adds to the cardiac concern.
How serious is the interaction between Ceritinib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium, and watch for beta-agonist adverse effects. Reassess the need for the combination inhaler if cardiac symptoms occur.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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