Drug interactions
Ceritinib + Vinblastine
Severity: Moderate
Ceritinib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and may reduce vinblastine clearance. This can increase vinblastine toxicity, including neutropenia, neuropathy and severe constipation.
What this interaction means in plain words
Ceritinib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Ceritinib inhibits CYP3A4-mediated metabolism of vinblastine.
What to do
Monitor blood counts and for neurotoxicity and bowel dysfunction. Consider lowering the vinblastine dose or choosing an alternative to ceritinib where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceritinib and Vinblastine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vinblastine
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Vinblastine?
MediHelp rates the interaction as moderate. Ceritinib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib is a CYP3A4 inhibitor and may reduce vinblastine clearance. This can increase vinblastine toxicity, including neutropenia, neuropathy and severe constipation.
How serious is the interaction between Ceritinib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neurotoxicity and bowel dysfunction. Consider lowering the vinblastine dose or choosing an alternative to ceritinib where possible.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
