Drug interactions
Ceritinib + Warfarin
Severity: Moderate
Ceritinib and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP2C9 in vitro and may increase S-warfarin exposure, raising INR and bleeding risk. Labeling advises avoiding or adjusting dose of narrow-therapeutic-index CYP2C9 substrates.
What this interaction means in plain words
Ceritinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Ceritinib inhibits CYP2C9, reducing S-warfarin metabolism.
What to do
Monitor INR frequently after starting or stopping ceritinib and reduce the warfarin dose if INR increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Warfarin?
MediHelp rates the interaction as moderate. Ceritinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP2C9 in vitro and may increase S-warfarin exposure, raising INR and bleeding risk. Labeling advises avoiding or adjusting dose of narrow-therapeutic-index CYP2C9 substrates.
How serious is the interaction between Ceritinib and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR frequently after starting or stopping ceritinib and reduce the warfarin dose if INR increases.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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