Drug interactions
Certolizumab pegol + Ozanimod
Severity: Moderate
Certolizumab pegol and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod reduces circulating lymphocytes, and certolizumab impairs TNF-mediated defenses, so combined use may increase infection risk. The lymphocyte effect of ozanimod can persist for some time after stopping.
What this interaction means in plain words
Certolizumab pegol and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Certolizumab pegol belongs to Musculoskeletal; Ozanimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from lymphocyte sequestration via S1P receptor modulation and TNF inhibition.
What to do
Monitor for signs of infection and check lymphocyte counts, especially when switching between agents. Consider the persistence of ozanimod's effects after discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Certolizumab pegol with Ozanimod?
MediHelp rates the interaction as moderate. Certolizumab pegol and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod reduces circulating lymphocytes, and certolizumab impairs TNF-mediated defenses, so combined use may increase infection risk. The lymphocyte effect of ozanimod can persist for some time after stopping.
How serious is the interaction between Certolizumab pegol and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check lymphocyte counts, especially when switching between agents. Consider the persistence of ozanimod's effects after discontinuation.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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