Drug interactions
Cetirizine + Methohexital
Severity: Moderate
Cetirizine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause central nervous system depression, so combining them can deepen sedation and prolong recovery after methohexital anesthesia. Cetirizine is less sedating than older antihistamines, but the effect is still additive in some patients.
What this interaction means in plain words
Cetirizine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cetirizine belongs to Respiratory; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression from the barbiturate anesthetic and the sedating antihistamine.
What to do
Monitor sedation level and respiratory status during and after methohexital use, and reduce the anesthetic dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Methohexital
Frequently asked questions
Can I take Cetirizine with Methohexital?
MediHelp rates the interaction as moderate. Cetirizine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause central nervous system depression, so combining them can deepen sedation and prolong recovery after methohexital anesthesia. Cetirizine is less sedating than older antihistamines, but the effect is still additive in some patients.
How serious is the interaction between Cetirizine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status during and after methohexital use, and reduce the anesthetic dose if needed.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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