Drug interactions
Cevimeline + Posaconazole
Severity: Moderate
Cevimeline and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase cevimeline levels, raising cholinergic adverse effects such as sweating, nausea, bradycardia and diarrhea.
What this interaction means in plain words
Cevimeline and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 (and CYP2D6 pathways) metabolism of cevimeline.
What to do
Monitor for cholinergic adverse effects and heart rate. Reduce cevimeline dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Posaconazole?
MediHelp rates the interaction as moderate. Cevimeline and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can increase cevimeline levels, raising cholinergic adverse effects such as sweating, nausea, bradycardia and diarrhea.
How serious is the interaction between Cevimeline and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects and heart rate. Reduce cevimeline dose if symptoms occur.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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