Drug interactions
Chloral hydrate + Lisdexamfetamine
Severity: Minor
Chloral hydrate and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate is sedating while lisdexamfetamine is a stimulant, so they have opposing effects on arousal and no reliable net effect can be predicted. Chloral hydrate may also sensitise the myocardium to sympathomimetic stimulation, potentially adding to arrhythmia risk.
What this interaction means in plain words
Chloral hydrate and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloral hydrate belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on arousal; a theoretical additive cardiac sensitisation to sympathomimetics.
What to do
Monitor heart rate and rhythm and the patient's response. Avoid using the stimulant to counteract hypnotic sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Chloral hydrate with Lisdexamfetamine?
MediHelp rates the interaction as minor. Chloral hydrate and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloral hydrate is sedating while lisdexamfetamine is a stimulant, so they have opposing effects on arousal and no reliable net effect can be predicted. Chloral hydrate may also sensitise the myocardium to sympathomimetic stimulation, potentially adding to arrhythmia risk.
How serious is the interaction between Chloral hydrate and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm and the patient's response. Avoid using the stimulant to counteract hypnotic sedation.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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