Drug interactions
Chloral hydrate + Metoclopramide
Severity: Moderate
Chloral hydrate and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate is a sedative-hypnotic, and metoclopramide can also cause drowsiness and extrapyramidal effects. Together they may deepen sedation and impair alertness.
What this interaction means in plain words
Chloral hydrate and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective dose of chloral hydrate and monitor for excessive sedation, especially in elderly or pediatric patients. Avoid other sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Metoclopramide?
MediHelp rates the interaction as moderate. Chloral hydrate and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate is a sedative-hypnotic, and metoclopramide can also cause drowsiness and extrapyramidal effects. Together they may deepen sedation and impair alertness.
How serious is the interaction between Chloral hydrate and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of chloral hydrate and monitor for excessive sedation, especially in elderly or pediatric patients. Avoid other sedatives where possible.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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