Drug interactions
Chlorambucil + Lomustine
Severity: Moderate
Chlorambucil and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are alkylating drugs that suppress bone marrow function. Given together, they can cause deeper and longer-lasting neutropenia, thrombocytopenia and anemia than either alone, raising the risk of infection and bleeding.
What this interaction means in plain words
Chlorambucil and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorambucil belongs to Oncology; Lomustine belongs to Oncology.
Why it happens
Additive myelosuppression from two alkylating agents with overlapping bone marrow toxicity.
What to do
Monitor complete blood counts frequently, including nadir counts, and reduce doses or delay cycles for significant cytopenias. Avoid overlapping courses unless the regimen is specifically designed for it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorambucil
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Chlorambucil with Lomustine?
MediHelp rates the interaction as moderate. Chlorambucil and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are alkylating drugs that suppress bone marrow function. Given together, they can cause deeper and longer-lasting neutropenia, thrombocytopenia and anemia than either alone, raising the risk of infection and bleeding.
How serious is the interaction between Chlorambucil and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, including nadir counts, and reduce doses or delay cycles for significant cytopenias. Avoid overlapping courses unless the regimen is specifically designed for it.
What other medicines interact with Chlorambucil?
MediHelp also lists interactions of Chlorambucil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Chlorambucil page.
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