Drug interactions
Chloramphenicol + Estradiol
Severity: Minor
Chloramphenicol and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and raise estradiol exposure. This could increase estrogenic side effects such as breast tenderness, nausea and fluid retention.
What this interaction means in plain words
Chloramphenicol and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Estradiol belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated estradiol metabolism.
What to do
No routine dose change is needed. Watch for estrogenic adverse effects during a short antibiotic course and adjust the estradiol dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Chloramphenicol with Estradiol?
MediHelp rates the interaction as minor. Chloramphenicol and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol may inhibit CYP3A4 and raise estradiol exposure. This could increase estrogenic side effects such as breast tenderness, nausea and fluid retention.
How serious is the interaction between Chloramphenicol and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for estrogenic adverse effects during a short antibiotic course and adjust the estradiol dose if they occur.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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