Drug interactions
Chloramphenicol + Finerenone
Severity: Major
Chloramphenicol and Finerenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise finerenone exposure through CYP3A4 inhibition, increasing the risk of hyperkalemia and hypotension. Finerenone is contraindicated with strong CYP3A4 inhibitors, and chloramphenicol's potency is uncertain.
What this interaction means in plain words
Chloramphenicol and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Finerenone belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition reduces finerenone clearance.
What to do
Avoid the combination if possible, or monitor serum potassium and renal function closely and consider holding finerenone during chloramphenicol therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Finerenone?
MediHelp rates the interaction as major. Chloramphenicol and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol may raise finerenone exposure through CYP3A4 inhibition, increasing the risk of hyperkalemia and hypotension. Finerenone is contraindicated with strong CYP3A4 inhibitors, and chloramphenicol's potency is uncertain.
How serious is the interaction between Chloramphenicol and Finerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or monitor serum potassium and renal function closely and consider holding finerenone during chloramphenicol therapy.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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