Drug interactions
Chloramphenicol + Fostamatinib
Severity: Moderate
Chloramphenicol and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and increase exposure to fostamatinib's active metabolite, potentially causing hypertension, diarrhea and elevated liver enzymes.
What this interaction means in plain words
Chloramphenicol and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Fostamatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of the active metabolite R406.
What to do
Monitor blood pressure, liver enzymes and neutrophil counts, and reduce the fostamatinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Chloramphenicol with Fostamatinib?
MediHelp rates the interaction as moderate. Chloramphenicol and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and increase exposure to fostamatinib's active metabolite, potentially causing hypertension, diarrhea and elevated liver enzymes.
How serious is the interaction between Chloramphenicol and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, liver enzymes and neutrophil counts, and reduce the fostamatinib dose if toxicity occurs.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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