Drug interactions
Chloramphenicol + Idelalisib
Severity: Moderate
Chloramphenicol and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is metabolized partly by CYP3A4 and aldehyde oxidase, so a CYP3A4 inhibitor may raise its levels. Higher exposure could increase hepatotoxicity, diarrhea or colitis, and pneumonitis.
What this interaction means in plain words
Chloramphenicol and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Idelalisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated idelalisib metabolism.
What to do
Monitor liver enzymes and for diarrhea or respiratory symptoms. Consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Idelalisib?
MediHelp rates the interaction as moderate. Chloramphenicol and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is metabolized partly by CYP3A4 and aldehyde oxidase, so a CYP3A4 inhibitor may raise its levels. Higher exposure could increase hepatotoxicity, diarrhea or colitis, and pneumonitis.
How serious is the interaction between Chloramphenicol and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for diarrhea or respiratory symptoms. Consider an alternative antibiotic.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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