Drug interactions
Chloramphenicol + Levamlodipine
Severity: Moderate
Chloramphenicol and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and increase levamlodipine exposure, leading to hypotension, peripheral edema or reflex tachycardia.
What this interaction means in plain words
Chloramphenicol and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Levamlodipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of levamlodipine.
What to do
Monitor blood pressure and edema during co-use and reduce the levamlodipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Chloramphenicol with Levamlodipine?
MediHelp rates the interaction as moderate. Chloramphenicol and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and increase levamlodipine exposure, leading to hypotension, peripheral edema or reflex tachycardia.
How serious is the interaction between Chloramphenicol and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during co-use and reduce the levamlodipine dose if hypotension or edema occurs.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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