Drug interactions
Chloramphenicol + Temsirolimus
Severity: Major
Chloramphenicol and Temsirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase concentrations of temsirolimus and its active metabolite sirolimus. This may increase adverse effects such as mucositis, cytopenias, hyperglycemia and pneumonitis.
What this interaction means in plain words
Chloramphenicol and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Temsirolimus belongs to Oncology.
Why it happens
CYP3A4 inhibition by chloramphenicol reduces the clearance of temsirolimus and sirolimus.
What to do
Choose an alternative antibiotic where possible. If used together, monitor closely for toxicity and consider a temsirolimus dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Temsirolimus?
MediHelp rates the interaction as major. Chloramphenicol and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol may increase concentrations of temsirolimus and its active metabolite sirolimus. This may increase adverse effects such as mucositis, cytopenias, hyperglycemia and pneumonitis.
How serious is the interaction between Chloramphenicol and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an alternative antibiotic where possible. If used together, monitor closely for toxicity and consider a temsirolimus dose reduction.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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