Drug interactions
Chloramphenicol + Upadacitinib
Severity: Moderate
Chloramphenicol and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise upadacitinib exposure through CYP3A4 inhibition, which may increase the risk of infections, cytopenias and other dose-related adverse effects. The effect is likely smaller than with strong inhibitors.
What this interaction means in plain words
Chloramphenicol and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Upadacitinib belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated upadacitinib metabolism.
What to do
Monitor for infection and laboratory abnormalities. Follow labeled dose reductions if chloramphenicol is regarded as a strong CYP3A4 inhibitor, or choose another antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Upadacitinib?
MediHelp rates the interaction as moderate. Chloramphenicol and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may raise upadacitinib exposure through CYP3A4 inhibition, which may increase the risk of infections, cytopenias and other dose-related adverse effects. The effect is likely smaller than with strong inhibitors.
How serious is the interaction between Chloramphenicol and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and laboratory abnormalities. Follow labeled dose reductions if chloramphenicol is regarded as a strong CYP3A4 inhibitor, or choose another antibiotic.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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