Drug interactions
Chloramphenicol + Valbenazine
Severity: Moderate
Chloramphenicol and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase exposure to valbenazine's active metabolite through CYP3A4 inhibition. This may cause somnolence and QT prolongation.
What this interaction means in plain words
Chloramphenicol and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Valbenazine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated valbenazine metabolism by chloramphenicol.
What to do
Reduce the valbenazine dose in line with labeling for strong CYP3A4 inhibitors and monitor for sedation and QT effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Chloramphenicol with Valbenazine?
MediHelp rates the interaction as moderate. Chloramphenicol and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may increase exposure to valbenazine's active metabolite through CYP3A4 inhibition. This may cause somnolence and QT prolongation.
How serious is the interaction between Chloramphenicol and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the valbenazine dose in line with labeling for strong CYP3A4 inhibitors and monitor for sedation and QT effects.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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