Drug interactions
Chlordiazepoxide-clidinium + Crofelemer
Severity: Minor
Chlordiazepoxide-clidinium and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut but is minimally absorbed, so systemic effects on chlordiazepoxide are unlikely. Any interaction is expected to be small.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible inhibition of intestinal CYP3A4 by crofelemer; systemic inhibition is unlikely given minimal absorption.
What to do
No routine dose change is needed. Be aware of increased sedation if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Crofelemer?
MediHelp rates the interaction as minor. Chlordiazepoxide-clidinium and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut but is minimally absorbed, so systemic effects on chlordiazepoxide are unlikely. Any interaction is expected to be small.
How serious is the interaction between Chlordiazepoxide-clidinium and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Be aware of increased sedation if symptoms appear.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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