Drug interactions
Chlordiazepoxide-clidinium + Esomeprazole
Severity: Minor
Chlordiazepoxide-clidinium and Esomeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole may slightly reduce the clearance of some benzodiazepines metabolized by CYP2C19 or CYP3A4. The effect is usually small, but it may modestly increase sedation.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Esomeprazole weakly inhibits CYP2C19, which may modestly reduce benzodiazepine metabolism.
What to do
No routine adjustment is needed; watch for increased drowsiness, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Esomeprazole?
MediHelp rates the interaction as minor. Chlordiazepoxide-clidinium and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esomeprazole may slightly reduce the clearance of some benzodiazepines metabolized by CYP2C19 or CYP3A4. The effect is usually small, but it may modestly increase sedation.
How serious is the interaction between Chlordiazepoxide-clidinium and Esomeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for increased drowsiness, especially in older patients.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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