Drug interactions
Chlordiazepoxide-clidinium + Fenfluramine
Severity: Moderate
Chlordiazepoxide-clidinium and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine can cause somnolence and may add to CNS depression with benzodiazepines, though stimulant properties could partially offset it. The net effect is unpredictable.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Fenfluramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic CNS effects; fenfluramine is serotonergic and sedating in some patients, while chlordiazepoxide enhances GABA-A activity.
What to do
Monitor sedation and alertness when starting or changing doses. Advise caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Fenfluramine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine can cause somnolence and may add to CNS depression with benzodiazepines, though stimulant properties could partially offset it. The net effect is unpredictable.
How serious is the interaction between Chlordiazepoxide-clidinium and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and alertness when starting or changing doses. Advise caution with driving.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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