Drug interactions
Chlordiazepoxide-clidinium + Fluconazole
Severity: Moderate
Chlordiazepoxide-clidinium and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4 and CYP2C19, which may raise chlordiazepoxide concentrations. This can lead to increased sedation, psychomotor impairment and prolonged effects, especially in older adults or those with liver disease.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4 and CYP2C19, decreasing oxidative metabolism of chlordiazepoxide.
What to do
Monitor for excess sedation and reduce the chlordiazepoxide dose if needed. Consider a benzodiazepine cleared by glucuronidation such as lorazepam if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Fluconazole?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP3A4 and CYP2C19, which may raise chlordiazepoxide concentrations. This can lead to increased sedation, psychomotor impairment and prolonged effects, especially in older adults or those with liver disease.
How serious is the interaction between Chlordiazepoxide-clidinium and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the chlordiazepoxide dose if needed. Consider a benzodiazepine cleared by glucuronidation such as lorazepam if needed.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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