Drug interactions
Chlordiazepoxide-clidinium + Modafinil
Severity: Minor
Chlordiazepoxide-clidinium and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may induce CYP3A4 and lower chlordiazepoxide exposure, while its wakefulness effect may partly oppose sedation. The net clinical effect is variable and generally modest.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Modafinil belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by modafinil plus opposing pharmacodynamic effects on arousal.
What to do
Monitor for reduced benzodiazepine efficacy and adjust the dose if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Modafinil
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Modafinil?
MediHelp rates the interaction as minor. Chlordiazepoxide-clidinium and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil may induce CYP3A4 and lower chlordiazepoxide exposure, while its wakefulness effect may partly oppose sedation. The net clinical effect is variable and generally modest.
How serious is the interaction between Chlordiazepoxide-clidinium and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced benzodiazepine efficacy and adjust the dose if clinically needed.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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