Drug interactions
Chlordiazepoxide-clidinium + Pregabalin
Severity: Major
Chlordiazepoxide-clidinium and Pregabalin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin and benzodiazepines have additive CNS depressant effects. This can lead to marked sedation, impaired psychomotor function and respiratory depression, particularly in the elderly or those with respiratory disease.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Pregabalin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS and respiratory depression.
What to do
Use the lowest effective doses for the shortest time. Monitor for sedation and respiratory depression, and counsel on driving risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Alzain 100 mg Capsules, Hard - SmPC sections 4.3/4.5 (class statement: other central nervous system (CNS) depressant medicinal products; "there are reports of respiratory failure, coma and deaths in patients taking pregabalin and opioids and/or other central nervous system (CNS) depressant medicin") — electronic medicines compendium (UK SmPC)
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Pregabalin?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pregabalin and benzodiazepines have additive CNS depressant effects. This can lead to marked sedation, impaired psychomotor function and respiratory depression, particularly in the elderly or those with respiratory disease.
How serious is the interaction between Chlordiazepoxide-clidinium and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time. Monitor for sedation and respiratory depression, and counsel on driving risk.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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